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Jan 3, 2018 · The study (“Amphiphilic Nanocarrier-Induced Modulation of PLK1 and miR-34a Leads to Improved Therapeutic Response in Pancreatic Cancer”) was published in Nature …
Accordingly, we used a microRNA-mimic to increase miR-34a together with siRNA to silence PLK1 oncogene. For in vivo dual-targeting of this combination, we developed a biodegradable …
Jan 2, 2018 · The research team examined pancreatic cancer cells and discovered an inverse correlation between the signatures of miR-34a, a tumor suppressant, and PLK1, a known …
For in vivo dual-targeting of this combination, we developed a biodegradable amphiphilic polyglutamate amine polymeric nanocarrier (APA).
Jan 2, 2018 · Here we show a potent combination of microRNA and siRNA delivered by an efficient nanocarrier to PDAC tumors. Using proteomic-microRNA profiles and survival data of …
Jan 2, 2018 · Following validation of miR-34a and PLK1 reciprocal levels in formalin-fixed-paraffin embedded (FFPE) sections obtained from STS versus LTS PDAC patients, we set to increase …
Since high miR-34a and low PLK1 expression levels correlated with favorable outcomes, we hypothesized that restoration of miR-34a together with silencing of PLK1 could improve the …
Jan 2, 2018 · Accordingly, we used a microRNA-mimic to increase miR-34a together with siRNA to silence PLK1 oncogene. For in vivo dual-targeting of this combination, we developed a …
Jan 2, 2018 · Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo.
Jan 2, 2018 · The research team examined pancreatic cancer cells and discovered an inverse correlation between the signatures of miR-34a, a tumor suppressant, and PLK1, a known …
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